programs in Economics, as well as current Ph.D. Programs in Economics :: Getting StartedĪ great resource for undergraduate and graduate students interested in applying to Ph.D. | Mathematics Major | What about the GRE? The efficacy and cost-effectiveness of photodynamic therapy in prevention of surgical site infection,The Spine Journal, Volume 19, Issue 9, Supplement, 2019, Page S138. Daniel Banaszek, Tom Inglis, Tamir Ailon, Raphaële Charest-Morin, Nicolas Dea, Charles G. Financial Impact of Surgical Site Infections on Hospitals: The Hospital Management Perspective. American College of Surgeons and Surgical Infection Society: Surgical Site Infection Guidelines, 2016 Update. It has been used in numerous Canadian hospitals for over ten years, with no serious adverse events reportedOndine is currently preparing for a US Phase 3 trial of its nasal photodisinfection, with further details to be announced later this year. Ondine’s nasal photodisinfection system has a CE mark and is approved in Canada and several other countries under the name Steriwave™. The findings of the Phase 2 study were consistent with previously reported research from Vancouver General Hospital (VGH) has shown that pre-surgical nasal photodisinfection resulted in a 78% reduction in SSIs among spine surgery patients. When illuminated with a specific wavelength of light, the photosensitizer is activated, causing an oxidative burst that is lethal to all types of pathogens. Ondine’s nasal photodisinfection is a patented technology which uses a proprietary, non-antibiotic photosensitizer to destroy pathogens. Universal treatment with nasal photodisinfection before surgery could have a transformative effect on preventing SSIs and potentially lead to substantial cost savings for the US healthcare system.”Īll patients in the study were treated with a single, 5-minute treatment of Ondine’s nasal photodisinfection, which eliminates infection-causing bacteria, viruses and fungi in the nose. These exciting results demonstrate the capabilities of this advanced infection prevention. “Our US Phase 2 trial met its primary endpoint last year, and these results confirm that a single, 5-minute treatment of nasal photodisinfection pre-surgically significantly reduces Staphylococcus aureus, a primary pathogen causing surgical site infections. ![]() Roger Andersen, MD, MPH, Ondine Biomedical’s VP, Regulatory and Medical Affairs said: A patient who develops an SSI will spend an average of five additional days in hospital, significantly increasing their recovery time and costs. SSIs are responsible for most hospital readmissions following surgery and are a significant cause of post-surgical morbidity and mortality, increasing the risk of mortality by 2- to 11-fold. aureus, including MRSA, is a major contributor to SSIs, and nasal decolonization has proven to be highly effective in preventing SSIs by eradicating S. The nose is a well-known reservoir of infection-causing pathogens. Of the 313 patients who underwent the treatment prior to surgery, 21% were found to have S. Moreover, the study results showed that Ondine’s nasal photodisinfection eliminated or significantly reduced Staphylococcus aureus, including MRSA, in 88% of carriers immediately after treatment. The Centers for Disease Control and Prevention (CDC) estimates that over 110,000 SSIs occur in the US each year, costing the healthcare system approximately $3.3 billion. The results indicate that patients who underwent Ondine’s nasal photodisinfection prior to surgery experienced 66% fewer surgical site infections (SSIs) than the US national average. ![]() (LON: OBI) presented detailed results from its US Phase 2 BENEFIT-aPDT clinical trial to the 33 rd European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) in Copenhagen, Denmark. Routine pre-surgical use of nasal photodisinfection could prevent tens of thousands of surgical site infections a year in the US alone
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